In a medium bowl, gently combine the ground beef, Worcestershire sauce, garlic powder, onion powder, pepper, and salt. Do not overmix.
Divide the mixture into 4 equal portions, roll each portion into a ball, and shape into patties.
Preheat the air fryer to 370°F. If it does not have a preheat setting, run it at 370°F for 5 minutes.
Arrange the patties in a single layer in the air fryer basket.
Cook for 6 minutes. Flip the patties and cook for another 3–4 minutes, or until the internal temperature reaches 160°F.
If using cheese, place a slice on each patty and cook for about 1 minute, or until melted.
Serve immediately with your favorite toppings.
Video
Notes
I find that 80/20 beef works best for this recipe to give the best flavor. If you decide to use a lean beef or ground turkey or ground chicken, then reduce the cook time by a few minutes to ensure that the patties do not get overcooked. Refrigerate any leftovers in an airtight container for up to 5 days. The nutritional information just includes the patties not the bun or the toppings for your burgers.