Place 12 bacon slices (cut in half to make 24 pieces) on a wire rack set over a foil-lined baking sheet.
Bake the bacon for 10 minutes, then transfer it to a paper towel-lined plate to cool slightly. Leave the oven on.
In a large mixing bowl, combine 24 peeled and deveined large shrimp, 1 Tbsp olive oil, 1 tsp paprika, 1 tsp dried oregano, ¼ tsp garlic powder, ½ tsp salt, and ½ tsp black pepper. Toss until the shrimp are evenly coated.
Wrap each shrimp with one half-slice of bacon and secure it with a toothpick.
Arrange the bacon-wrapped shrimp on a foil-lined baking sheet in a single layer.
Bake for 10–12 minutes, flipping the shrimp halfway through cooking, until the shrimp are pink and the bacon is crispy.
Remove from the oven and let rest for 5 minutes.
Serve with lemon wedges, if desired, and enjoy.
Notes
Do not use thick cut bacon for this recipe. It takes too long to cook and is difficult to wrap around the shrimp. Refrigerate the leftovers in an airtight container for up to 3 days.