Place the chicken breasts in the bottom of a 6-quart crock pot.
Pour the heavy whipping cream and chicken broth over the chicken. Add the butter, Cajun seasoning, and garlic powder. Stir the liquids gently to combine.
Cover and cook on Low for 4–6 hours or High for 2–3 hours, until the chicken reaches an internal temperature of 165°F.
Remove the chicken from the crock pot. Shred it with two forks or dice it into bite-size pieces, then return it to the crock pot.
Stir in the uncooked penne pasta. Cover and cook on High for 20–30 minutes, stirring occasionally, until the pasta is tender.
Stir in the Parmesan cheese until melted and the sauce is creamy and well combined.
Serve warm and enjoy!
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Notes
If you are sensitive to spice, reduce the cajun seasoning in half in this recipe. Refrigerate the leftovers in an airtight container for up to 5 days.